a tool for identifying drug-targetable redox-active disulphides

Mast cell protease 2

Intramolecular

Cysteine 174 and cysteine 187

A redox-regulated disulphide may form within Mast cell protease 2 between cysteines 174 and 187 (168 and 182 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

the structure of rat mast cell protease ii at 1

Structure deposition date

1984-09-10

Thiol separation (Å)

2

Half-sphere exposure sum ?

76

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

174

Residue number B

187

Peptide name

Mast cell protease 2

Ligandability

Cysteine 174 of Mast cell protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Mast cell protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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